Bradykinin-potentiating peptide 14a

Bradykinin-potentiating peptide 14a

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

Pyroglutamic acid Pyr-WPRPTP-OH

Pyroglutamic acid Pyr-Trp-Pro-Arg-Pro-Thr-Pro-OH

7

95.03%

C₄₁H₅₇N₁₁O₁₀

863.95

Synthetic

Powder

Bradykinin-potentiating peptide 14a is a bradykinin-potentiating peptide found in the female venom of Bothrops jararaca, but not in male one's, and is identified by de novo sequencing as cleaved BPP-11a lacking the C-terminal Q-I-P-P sequence.
Bradykinin-potentiating peptide 14a is one of the nineteen different BPPs (bradykinin-potentiating peptides) identified in the venom of B. jararaca. BPPs are short proline-rich oligopeptides that potentiate the activity of bradykinin, leading to an anti-hypertensive effect, with each of them haveeach with varying bradykinin-potentiating activities and inhibition of angiotensin I converting enzyme. They are encoded by a precursor protein in the venom gland of B. jararaca, which consists of seven BPPs aligned in tandem.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Pimenta DC, Prezoto BC, Konno K, et al. Mass spectrometric analysis of the individual variability of Bothrops jararaca venom peptide fraction. Evidence for sex-based variation among the bradykinin-potentiating peptides. Rapid Commun Mass Spectrom. 2007;21(6):1034-42.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.