BMP2pp peptide

BMP2pp peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-KIPKASSVPTELSAISTLYL-OH

H-Lys-Ile-Pro-Lys-Ala-Ser-Ser-Val-Pro-Thr-Glu-Leu-Ser-Ala-Ile-Ser-Thr-Leu-Tyr-Leu-OH

20

95.58%

C₉₇H₁₆₄N₂₂O₃₀

2118.46

Synthetic

Powder

BMP2pp is a peptide corresponding to residues 73-92 of the knuckle epitope of bone morphogenetic protein-2 (BMP-2) which inhibits the binding of human recombinant BMP-2 to both BMP receptors type IA and type II. BHP2pp has the same receptor binding capacity and osteogenic properties as the full BMP-2 protein and can promote the formation and regeneration of bone and cartilage, participate in organogenesis, cell differentiation, cell proliferation and apoptosis, but is more stable. In models of artificial joint replacement wear, BMP2pp can ameliorate the Titanium (Ti) mediated impairment in osteogenic potential of human placenta derived mesenchymal stem cells (hPMSCs), suppress the M1 polarization of macrophages through inhibition of the activation of the NF-κB signaling pathway, and ameliorate Ti-induced bone osteolysis.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Saito et al (2003) Activation of osteo-progenitor cells by a novel synthetic peptide derived from the bone morphogenetic protein-2 knuckle epitope. Biochim Biophys Acta 1651(1-2) 60 PMID: 14499589
• Madl (2014) Presentation of BMP-2 mimicking peptides in 3D hydrogels directs cell fate commitment in osteoblasts and mesenchymal stem cells. Biomacromolecules 15(2) 445 PMID: 24400664
• Wang et al (2023) BMP-2 functional polypeptides relieve osteolysis via bi-regulating bone formation and resorption coupled with macrophage polarization. NPJ Regen Med. 8(1) 6 PMID: 36759627

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.