BMP-7 derived peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

• KPSSAPTQLN peptide is a short peptide derived from bone morphogenetic protein - 7 (BMP - 7). It has a length of 10 amino acids (101–110 amino acid residue sequence of BMP - 7).
• This peptide plays a significant role in promoting osteoblast functions. In vitro studies have shown that when osteoblasts were cultured in the presence of this peptide, their density increased notably after 5 days, and they exhibited a more spread and larger average size morphology after 1 and 3 days of culture compared to controls. Additionally, it was found that peptide combinations involving KPSSAPTQLN, such as the combination with SNVILKKYRN, further enhanced osteoblast proliferation. The peptide also showed potential in enhancing total collagen content in osteoblasts after 21 days of culture. Overall, KPSSAPTQLN peptide holds great promise for applications in bone regeneration and orthopedic biomaterials, as it can effectively stimulate osteoblast activities and contribute to improved bone growth and repair processes. It may be used in the development of novel biomaterials or drug delivery systems to enhance the osseointegration of implants and promote better outcomes in orthopedic treatments.

• Chen Y, Webster TJ. Increased osteoblast functions in the presence of BMP-7 short peptides for nanostructured biomaterial applications. J Biomed Mater Res A. 2009 Oct;91(1):296-304. doi: 10.1002/jbm.a.32246. PMID: 18980196; PMCID: PMC2732755.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.