BMP-2 derived peptide

BMP-2 derived peptide

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-KIPKASSVPTELSAISTLYLGGC-NH2

H-Lys-Ile-Pro-Lys-Ala-Ser-Ser-Val-Pro-Thr-Glu-Leu-Ser-Ala-Ile-Ser-Thr-Leu-Tyr-Leu-Gly-Gly-Cys-NH2

23

95.86%

C₁₀₄H₁₇₆N₂₆O₃₂S

2334.72

Synthetic

Powder

BMP-2 derived peptide, also known as bone morphogenetic protein 2 (BMP-2) derived peptide, corresponds to residues 73-92 of the knuckle epitope of BMP-2. BMP-2 derived peptide significantly inhibits the binding of recombinant human BMP-2 to both BMP receptors type IA and type II and also promotes the expression of osteocalcin mRNA and induces ectopic calcification in rat calf muscle. BMP-2 derived peptide may one of the receptor binding sites on BMP-2 and may stimulate bone precursor cells to induce calcification.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Saito et al (2003) Activation of osteo-progenitor cells by a novel synthetic peptide derived from the bone morphogenetic protein-2 knuckle epitope. Biochim. Biophys. Acta. 1651(1-2) 60 PMID: 14499589
• Balakin et al (2019) Quantitative analysis of BMP-2 derived peptide covalently grafted onto oxidized detonation nanodiamonds. Carbon 152 740 ISSN 0008-6223 https://doi.org/10.1016/j.carbon.2019.05.064

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.