Recombinant BMAL1 protein (His tag)

• DataSheet
• COA (Batch NP456541)
• Material Safety Data Sheets (MSDS)

Recombinant BMAL1 (242-443) Fragment: A high-purity, functional protein fragment encompassing the PAS 2 domain of the human Basic helix-loop-helix ARNT-like protein 1 (BMAL1). This product is an essential tool for investigating circadian clock mechanisms, transcriptional regulation, and domain-specific interactions in circadian biology research.

BMAL1 is a core transcriptional activator of the circadian clock, forming heterodimers with CLOCK or NPAS2 to drive rhythmic gene expression by binding E-box promoter elements. It regulates diverse physiological processes, including metabolism, immune function, neurogenesis, and hormone signaling, through the transcription/translation feedback loop. The full-length protein localizes to the nucleus and cytoplasm, with nucleocytoplasmic shuttling critical for its function. This recombinant fragment (residues 242-443) contains the PAS 2 domain, enabling focused studies on dimerization, ligand binding, and structural aspects of circadian regulation without interf

MSKIKHHHHH HGGSGARRSF FCRMKCNRPS VKVEDKDFPS TCSKKKADRK SFCTIHSTGY LKSWPPTKMG LDEDNEPDNE
GCNLSCLVAI GRLHSHVVPQ PVNGEIRVKS MEYVSRHAID GKFVFVDQRA TAILAYLPQE LLGTSCYEYF HQDDIGHLAE
CHRQVLQTRE KITTNCYKFK IKDGSFITLR SRWFSFMNPW TKEVEYIVST NTVVLA