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Product Name
Recombinant BEST1 protein (His tag)
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Description
Recombinant Bestrophin homolog 1 (83-242) fragment from Caenorhabditis elegans, representing a stable and soluble unit of this calcium-activated chloride channel protein, ideal for structural and biochemical studies.
Bestrophin homolog 1 (BEST-1) functions as a ligand-gated anion channel that facilitates chloride ion transport across cell membranes upon calcium activation. This calcium-gated chloride channel activity is essential for various cellular processes involving anion homeostasis and signaling. The full-length protein is localized to the cell membrane as a multi-pass membrane protein, where it performs its critical role in regulating chloride flux in response to calcium signals. The selected fragment (residues 83-242) was computationally designed to provide a stable, soluble domain suitable for detailed structural characterization and functional analysis of this important ion channel protein.
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Protein name
Bestrophin homolog 1
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Uniprot ID
Q17528
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Gene Name
best-1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 83-242 aa (Q17528) were fused with 6His tag.
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Protein Species
Caenorhabditis elegans
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Molecular weight
Predictes a molecular mass of 20.89 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 21 kDa band.
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Purity
>87%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"