Recombinant BAMBI protein (His tag)

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Recombinant Human BAMBI (BMP and activin membrane-bound inhibitor homolog) Fragment (aa 21-107) is a high-purity, soluble protein fragment designed for structural and biochemical studies. This 87-amino acid fragment represents a stable, computationally optimized region of the protein, ideal for investigating its role as a negative regulator of TGF-beta signaling.

The full-length BAMBI protein, also known as Non-metastatic gene A protein or Putative transmembrane protein NMA, functions as a negative regulator of TGF-beta signaling pathways. As a single-pass type I membrane protein localized to the cell membrane, BAMBI plays a crucial role in modulating cellular responses to TGF-beta family cytokines, which are involved in diverse processes including cell proliferation, differentiation, and apoptosis. This recombinant fragment provides researchers with a valuable tool for studying the molecular mechanisms underlying BAMBI's inhibitory function without the complications associated with full-length membrane protein expression.