Recombinant BAG6 protein (His tag)

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Recombinant Human BAG6 Protein Fragment (724-946) is a high-purity, stable protein fragment derived from the Large proline-rich protein BAG6, a key ATP-independent molecular chaperone involved in protein quality control and cellular stress response. This fragment is specifically designed for structural and biochemical studies, offering researchers a soluble and functional unit for investigating BAG6's mechanisms in protein homeostasis and disease pathways.

The full-length BAG6 protein, encoded by the BAG6 gene in Homo sapiens, functions as an ATP-independent molecular chaperone that prevents aggregation of misfolded proteins and plays a critical role in cytosolic protein quality control. It operates within the BAG6/BAT3 complex to maintain client proteins in a soluble state, facilitating their proper delivery to the endoplasmic reticulum or targeting to the proteasome for degradation. BAG6 is involved in multiple cellular processes, including tail-anchored protein membrane insertion, endoplasmic reticulum-associated degradation (ERAD), DNA damage-induced apoptosis via p53 acetylation enhancement, and immune response modulation through exosome-mediated release and interaction with natural killer cells. It localizes primarily to the cytoplasm and nucleus, with extracellular secretion via exosomes in certain contexts, and its functions span protein folding surveillance, stress adaptation, and apoptosis regulation, making it a significant target for research in cancer, neurodegeneration, and cellular homeostasis.