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Product Name
Recombinant ATX2 protein (His tag)
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Description
This recombinant protein product features a 216-amino acid fragment (residues 257-472) of human Ataxin-2 (ATXN2), encompassing the Sm functional domain. It serves as a specialized tool for investigating domain-specific mechanisms related to EGFR trafficking regulation.
Ataxin-2, encoded by the ATXN2 gene, plays a critical role in EGFR trafficking by acting as a negative regulator of endocytic EGFR internalization at the plasma membrane. This function positions it as a key modulator of receptor signaling pathways. The full-length protein is localized in the cytoplasm, where it contributes to cellular processes relevant to both normal physiology and disease states, including spinocerebellar ataxia type 2.
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Protein name
Ataxin-2
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Uniprot ID
Q99700
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Gene Name
ATXN2; ATX2; SCA2; TNRC13
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 257-472 aa (Q99700) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 26.07 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 31 kDa band.
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Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"