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  • APP 17mer peptide (204-220AA of APP695)

APP 17mer peptide (204-220AA of APP695)

Not For Human Use, Lab Use Only.

Cat.#: 318741

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* Buy 1 get 1 free (?) What is TFA?

Special Price 147.20 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    APP 17mer peptide (204-220AA of APP695)
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    Ac-DDSDVWWGGADTDYADG-NH2
  • Sequence
    Ac-Asp-Asp-Ser-Asp-Val-Trp-Trp-Gly-Gly-Ala-Asp-Thr-Asp-Tyr-Ala-Asp-Gly-NH2
  • Length (aa)
    17
  • Peptide Purity (HPLC)
    95.2%
  • Molecular Formula
    C81H104N20O33
  • Molecular Weight
    1885.79
  • Source
    Synthetic
  • Form
    Powder
  • Description
    APP 17mer peptide (204-220AA of APP695) is a 17–amino acid peptide corresponding to the GABABR1a(gamma-aminobutyric acid type B receptor subunit 1a) binding region within APP (Amyloid-beta precursor protein) suppressed in vivo spontaneous neuronal activity in the hippocampus of anesthetized Thy1-GCaMP6s mice. The sequence of APP 17mer peptide is: Ac-DDSDVWWGGADTDYADG-NH2. APP 17mer peptide could bind to sushi 1 domain of GABABR1a with a KD of 810 nM, in the same ragne as the binding affinity of the entire linker region. APP 17-mer peptide mimics the effects of sAPPα on GABABR1a dependent inhibition of synaptic vesicle release. Also, APP 17-mer peptide suppresses neuronal activity of CA1 pyramidal cells in vivo.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Rice HC, de Malmazet D, Schreurs A, et al. Secreted amyloid-u03b2 precursor protein functions as a GABABR1a ligand to modulate synaptic transmission. Science. 2019;363(6423)
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight

Peptide Property

  • Analysed Sequence:A
  • Chemical Formula:A
  • Sequence length:A
  • Extinction coefficient:A M-1cm-1
  • GRAVY:A
  • Mw average:A
  • Theoretical pI:A
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

X: Hydrophobic uncharged residues, like F I L M V W A and P

X: Basic residues, like R K H

X: Acidic residues, like D E

X: Polar uncharged residues, like G S T C N Q and Y

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"