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  • Antibiotic peptide, Loloatin A

Antibiotic peptide, Loloatin A

Not For Human Use, Lab Use Only.

Cat.#: 308183

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Product Information

  • Product Name
    Antibiotic peptide, Loloatin A
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    NDYVKLYPFF
  • Sequence
    cyclo[Asn-Asp-Tyr-Val-Orn-Leu-D-Tyr-Pro-Phe-D-Phe]
  • Length (aa)
    10
  • Peptide Purity (HPLC)
    98.44%
  • Molecular Weight
    1273.46
  • PubChem CID
    16145001
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Loloatin A is a cyclic decapeptide antibiotic isolated from the Gram-positive spore-forming bacterium Brevibacillus laterosporus. It exhibits potent inhibitory activity against cyanobacteria, including Microcystis aeruginosa. The peptide is characterized by its unique cyclic structure, which contributes to its stability and bioactivity. Loloatin A disrupts essential physiological functions in cyanobacterial cells, leading to growth inhibition and cell lysis.

    The algicidal activity of Loloatin A is attributed to its ability to interfere with cellular processes such as membrane integrity and metabolic pathways. Transcriptomic analyses reveal that exposure to Loloatin A induces significant changes in gene expression related to amino acid metabolism, lipid degradation, and energy production in target cyanobacteria. The peptide's mechanism involves the secretion of hydrolytic enzymes and secondary metabolites, which collectively contribute to its algicidal effects.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Krachkovskiĭ SA, Sobol' AG, Ovchinnikova TV, Tagaev AA, Iakimenko ZA, Azizbekian RR, Kuznetsova NI, Shamshina TN, Arsen'ev AS. Vydelenie, biologicheskie svoĭstva i prostranstvennaia struktura antibiotika loloatina A [Isolation, biological properties, and spatial structure of an antibiotic loloatin A]. Bioorg Khim. 2002 Jul-Aug;28(4):298-302. Russian. doi: 10.1023/a:1019531505769. PMID: 12197385.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"