Anti-Ly108/SLAMF6 antibody

Anti-Ly108/SLAMF6 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

Rabbit monoclonal to Ly108/SLAMF6

IHC-P

Human Ly108 / SLAMF6
No cross-reactivity in ELISA with Human SLAMF7

KALI antibody; KALI antibody; NTBA antibody; CD352 antibody; KALIb antibody; Ly108 antibody; NTB-A antibody; SF2000 antibody; KAL1 antibody; NTBA antibody; KAL1b antibody; Ly108 antibody; NTB-A antibody; SF2000 antibody; Ly108 antibody; MGC104953 antibody; FLJ50657 antibody; KAL1 antibody; KALIb antibody; Ly108 antibody; NTBA antibody; NTB-A antibody; NTBA antibody; NTB-A antibody; RP11-528G1.1 antibody; SF2000 antibody; SLAMF6 antibody; SF2000 antibody; Slamf6 antibody; KAL1b antibody

Rabbit IgG

This antibody was obtained from a rabbit immunized with purified, recombinant Human Ly108 / SLAMF6 (rh Ly108 / SLAMF6; Q96DU3-1; Met1-Met226).

Monoclonal

0.2 μm filtered solution in PBS

This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.

SLAM family member 6, also known as Activating NK receptor, NK-T-B-antigen, NTB-A, SLAMF6, KALI and Ly108, is a single-pass type I membrane protein which belongs to the CD2 subfamily of the immunoglobulin superfamily. SLAMF6 / Ly108 contains one Ig-like (immunoglobulin-like) domain. It is expressed by all (resting and activated) natural killer cells (NK), T- and B-lymphocytes. SLAMF6 / Ly108 triggers cytolytic activity only in natural killer cells (NK) expressing high surface densities of natural cytotoxicity receptors. SLAMF6 / Ly108 is a homodimer. It interacts with PTN6 and, upon phosphorylation, with PTN11 and SH2D1A/SAP. SLAMF6 / Ly108 undergoes tyrosine phosphorylation and associates with the Src homology 2 domain-containing protein (SH2D1A) as well as with SH2 domain-containing phosphatases (SHPs). It may function as a coreceptor in the process of NK cell activation. SLAMF6 / Ly108 can also mediate inhibitory signals in NK cells from X-linked lymphoproliferative patients.

• Gray CW. et al., 2000, Eur J Biochem. 267 (18): 5699-710.
• Bottino C. et al., 2001, J Exp Med. 194 (3): 235-46.
• Valdez PA. et al., 2004, J Biol Chem. 279 (18): 18662-9.
• Claus M. et al., 2007, Front Biosci. 13: 956-65.