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  • Angiotensin I-converting enzyme inhibitor, Acein-2 peptide

Angiotensin I-converting enzyme inhibitor, Acein-2 peptide

Not For Human Use, Lab Use Only.

Cat.#: 303002

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* Buy 1 get 1 free (?) What is TFA?

Special Price 75.90 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    Angiotensin I-converting enzyme inhibitor, Acein-2 peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    LIY
  • Sequence
    H-Leu-Ile-Tyr-OH
  • Length (aa)
    3
  • Peptide Purity (HPLC)
    97.3%
  • Molecular Formula
    C21H33N3O5
  • Molecular Weight
    407.5
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Acein-2 is a tripeptide with the sequence Leu-Ile-Tyr, identified as a novel angiotensin-I-converting enzyme (ACE) inhibitory peptide derived from a tryptic hydrolysate of human plasma. It corresponds to fragment (518-520) of human K2-macroglobulin. The synthetic tripeptide exhibits potent dose-dependent ACE inhibition, with an IC50 value of 0.82 μmol/L. Kinetic analysis using Lineweaver-Burk plots indicates that Acein-2 acts as a non-competitive inhibitor of ACE.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Murray BA, FitzGerald RJ. Angiotensin converting enzyme inhibitory peptides derived from food proteins: biochemistry, bioactivity and production. Curr Pharm Des. 2007;13(8):773-91. doi: 10.2174/138161207780363068. PMID: 17430180.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"