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  • Amyloid Beta peptide (21-40), human

Amyloid Beta peptide (21-40), human

Not For Human Use, Lab Use Only.

Cat.#: 318951

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* Buy 1 get 1 free (?) What is TFA?

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Product Information

  • Product Name
    Amyloid Beta peptide (21-40), human
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-AEDVGSNKGAIIGLMVGGVV-OH
  • Sequence
    H-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
  • Length (aa)
    20
  • Peptide Purity (HPLC)
    95.69%
  • Molecular Formula
    C81H140N22O27S
  • Molecular Weight
    1886.16
  • Source
    Synthetic
  • Form
    Powder
  • Description
    The three GxxxG repeating motifs from the 21-40aa C-terminal region of β-amyloid (Aβ) peptide play a significant role in regulating the aggregation kinetics of the peptide. Mutation of these glycine residues to leucine greatly accelerates the fibrillation process but generates a varied toxicity profile.

    The β-Amyloid series peptides can be treated with 1,1,1,3,3,3-hexafluoro-2-propanol (HFlP) to guarantee a monomeric state, lyophilized, and stored at-20 °C until use.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • La Manna, S., Di Natale, C., Panzetta, V., Leone, M., Mercurio, F. A., Cipollone, I., Monti, M., Netti, P. A., Ferraro, G., Terán, A., Sánchez-Peláez, A. E., Herrero, S., Merlino, A., & Marasco, D. (2024). A Diruthenium Metallodrug as a Potent Inhibitor of Amyloid-β Aggregation: Synergism of Mechanisms of Action. Inorganic chemistry, 63(1), 564–575. https://doi.org/10.1021/acs.inorgchem.3c03441
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"