AMPR-22 peptide

AMPR-22 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-KKMMKKGGKFGTFMAIGGIR-OH

H-Lys-Lys-Met-Met-Lys-Lys-Gly-Gly-Lys-Phe-Gly-Thr-Phe-Met-Ala-Ile-Gly-Gly-Ile-Arg-OH

20

95.49%

C₉₈H₁₆₈N₂₈O₂₂S₃

2186.74

Synthetic

Powder

AMPR-22 is an optimised antimicrobial peptide derived from reactive oxygen species modulator 1 (Romo1), a mitochondrial protein encoded by the nucleus which is a nonselective cation channel in the mitochondrial inner membrane. AMPR-22 shows broad-spectrum antimicrobial activity against 17 sepsis causing bacteria, including multidrug resistant (MDR) strains, by inducing membrane permeabilization. In vivo, AMPR-22 enables a remarkable survival rate in mice injected with MDR bacteria in murine models of sepsis.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• You et al (2021) A Novel Peptide Derived from the Transmembrane Domain of Romo1 Is a Promising Candidate for Sepsis Treatment and Multidrug-Resistant Bacteria. Int J Mol Sci. 22(15) 8243 PMID: 34361008

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.