α-CGRP (mouse, rat) peptide
Not For Human Use, Lab Use Only.
Cat.#: 315976
Special Price 578.10 USD
Availability:
4 weeks
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Product Name
α-CGRP (mouse, rat) peptide
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Documents
Batch to batch variation of the purity
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Sequence Shortening
H-SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2 (Disulfide bridge:Cys2-Cys7)
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Sequence
H-Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2 (Disulfide bridge:Cys2-Cys7)
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Length (aa)
37
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Peptide Purity (HPLC)
97.2%
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Molecular Formula
C162H262N50O52S2
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Molecular Weight
3806.23
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CAS No.
83651-90-5
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Source
Synthetic
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Form
Powder
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Description
α-CGRP (calcitonin gene-related peptide) is a 37-amino acid neuropeptide widely distributed in the brain, including the hippocampus of mice and rats. It is encoded by the calcitonin/α-CGRP gene and has been implicated in modulating neuronal activity and plasticity. Studies show that kainic acid (KA) administration upregulates hippocampal α-CGRP mRNA levels, with peak expression observed 6–12 hours post-treatment, returning to baseline by 24 hours. Immunohistochemical analyses reveal α-CGRP presence in mossy cell somata, terminals, and interneurons of the rodent hippocampus.
Experimental evidence suggests α-CGRP influences excitotoxicity responses. KA-induced neuronal death in the hippocampal CA3 region is more pronounced in wild-type mice compared to α-CGRP knockout models, indicating a regulatory role in neuronal vulnerability. Further, inhibition of α-CGRP release attenuates KA-mediated pyramidal cell damage, supporting its involvement in excitotoxic pathways. These findings highlight α-CGRP as a modulator of hippocampal neuronal responses to excitatory stimuli.
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Storage Guidelines
Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
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References
- Park SH, Sim YB, Kim CH, Lee JK, Lee JH, Suh HW. Role of α-CGRP in the regulation of neurotoxic responses induced by kainic acid in mice. Peptides. 2013 Jun;44:158-62. doi: 10.1016/j.peptides.2013.04.001. Epub 2013 Apr 12. PMID: 23587546.
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About TFA salt
Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.
Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.
Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.
In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.
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Molar Concentration Calculator
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Dilution Calculator
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Percent Concentration Calculator
Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)
Related Products / Services
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• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"