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Product Name
Recombinant ALMS1 protein (His tag)
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Description
This recombinant protein product features a stable 149-amino acid fragment (residues 1174-1322) of Drosophila melanogaster Centrosome-associated protein Alms1a, designed for structural and biochemical studies of centrosome regulation and asymmetric cell division mechanisms.
Centrosome-associated protein Alms1a (Alstrom syndrome protein 1 homolog a) plays a critical role in centrosome duplication within asymmetrically dividing germline stem cells, ensuring proper production of centrosomes and centrioles in downstream germ cells. The protein functions at the microtubule organizing center, specifically localizing to centrosomes and centrioles, with asymmetric distribution to mother centrosomes in germline stem cells where it colocalizes with SAK to facilitate daughter centriole duplication. This centrosomal regulation is essential for maintaining stem cell asymmetry and proper germ cell development.
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Protein name
Centrosome-associated protein Alms1a
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Uniprot ID
Q5BI31
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Gene Name
Alms1a; EG:66A1.2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1174-1322 aa (Q5BI31) were fused with 6His tag.
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Protein Species
Drosophila melanogaster
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Molecular weight
Predictes a molecular mass of 18.87 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 19 kDa band.
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Purity
>89%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
Related Products / Services
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"