Alarin (human) peptide

Alarin (human) peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

APAHRSSTFPKWVTKTERGRQPLRS

H-Ala-Pro-Ala-His-Arg-Ser-Ser-Thr-Phe-Pro-Lys-Trp-Val-Thr-Lys-Thr-Glu-Arg-Gly-Arg-Gln-Pro-Leu-Arg-Ser-OH

25

97.5%

C₁₂₇H₂₀₅N₄₃O₃₅

2894.29

909409-86-5

Synthetic

Powder

Alarin is derived from a splice variant of galanin-like peptide (GALP) RNA. It shows potent and dose-dependent vasoconstrictor and anti-edema activity in the cutaneous microvasculature, as was also observed with other members of the galanin peptide family. Since alarin only shares five amino acids with GALP it is unlikely that the peptide can activate GALP-specific receptors. Originally discovered as neuropeptide in 2006 (Santic R et al 2006). It was termed alarin because of the N-terminal alanine and the C-terminal serine. In 2013, this peptide was demonstrated to have antimicrobial activity as well. Active against Gram-negative E. coli ML-35. Deletion of the conserved N-terminal sequence (APAHR) reduced its antimicrobial activity, suggesting that APAHR is essential for its antimicrobial activity. Electron microscopy showed that alarin caused bacterial membrane blebbing. Updated 11/26/2013. Alarin has Antibacterial activity. Alarin was found in brain, Homo sapiens.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• R.Santic et al., J. Mol. Neurosci., 29, 145 (2006)
• R.Santic et al., Proc. Natl. Acad. Sci. USA, 104, 10217 (2007)

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.