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Product Name
Recombinant AHSP protein (His tag)
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Description
Recombinant Alpha-hemoglobin-stabilizing protein (AHSP) fragment (residues 1-102) from Homo sapiens, engineered to provide a stable and soluble unit ideal for structural and biochemical studies. This fragment captures the essential chaperone activity of AHSP, supporting research into hemoglobin stability and erythroid cell development.
Alpha-hemoglobin-stabilizing protein (AHSP), also known as Erythroid differentiation-related factor, functions as a critical chaperone in erythroid cells. It specifically prevents the aggregation of free alpha-hemoglobin during normal development, thereby protecting cells from harmful precipitation. AHSP is localized in the cytoplasm and is implicated in modulating pathological conditions such as beta-thalassemia, where excess alpha-hemoglobin occurs. This recombinant fragment (1-102) represents a stable, soluble domain selected for its suitability in experimental analyses, enabling deeper insights into AHSP's protective mechanisms and therapeutic potential.
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Protein name
Alpha-hemoglobin-stabilizing protein
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Uniprot ID
Q9NZD4
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Gene Name
AHSP; EDRF; ERAF
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 1-102 aa (Q9NZD4) were fused with C-terminal 6His tag.
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Sequence
MALLKANKDL ISAGLKEFSV LLNQQVFNDP LVSEEDMVTV VEDWMNFYIN YYRQQVTGEP QERDKALQEL RQELNTLANP FLAKYRDFLK SHELPSHPPP SSLEHHHHHH
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 12.89 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 14 kDa band.
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Purity
>90%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Validations
Recombinant AHSP protein (His tag) SDS-PAGE
M: Marker; Lane 1: AHSP; Lane 2: BSA
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"