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Product Name
Recombinant AEBP2 protein (His tag)
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Description
Recombinant Human Zinc Finger Protein AEBP2 Fragment (Amino Acids 391-517) is a highly stable and soluble protein fragment designed for structural and biochemical studies. This product offers researchers a reliable tool to investigate the molecular mechanisms of AEBP2, an essential accessory subunit of the Polycomb repressive complex 2 (PRC2) involved in epigenetic regulation.
The full-length AEBP2 protein functions as a critical accessory subunit of the Polycomb repressive complex 2 (PRC2), which mediates trimethylation of histone H3 at lysine 27 (H3K27me3). This epigenetic modification leads to transcriptional repression of target genes, playing a fundamental role in gene regulation and cellular differentiation. AEBP2 contributes to the proper nucleosome localization of the PRC2 complex, enhancing its chromatin binding and enzymatic activity. The protein is exclusively nuclear and localizes to chromatin as part of the PRC2 complex, where it participates in maintaining transcriptional silencing through epigenetic mechanisms.
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Protein name
Zinc finger protein AEBP2
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Uniprot ID
Q6ZN18
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Gene Name
AEBP2
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
DNA encoding 391-517 aa (Q6ZN18) were fused with 6His tag.
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Protein Species
Human
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Molecular weight
Predictes a molecular mass of 16.49 kDa. In SDS-PAGE under reducing conditions, it migrates as an approximately 16 kDa band.
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Purity
>86%, by SDS-PAGE with Coomassie Brilliant Blue staining.
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Activity
Not tested.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"