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  • Activated Protein C (390-404) (human) peptide

Activated Protein C (390-404) (human) peptide

Not For Human Use, Lab Use Only.

Cat.#: 316067

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* Buy 1 get 1 free (?) What is TFA?

Special Price 189.80 USD

Availability: 1-2 weeks
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Product Information

  • Product Name
    Activated Protein C (390-404) (human) peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    YGVYTKVSRYLDWIH
  • Sequence
    H-Tyr-Gly-Val-Tyr-Thr-Lys-Val-Ser-Arg-Tyr-Leu-Asp-Trp-Ile-His-OH
  • Length (aa)
    15
  • Peptide Purity (HPLC)
    96.1%
  • Molecular Formula
    C91H130N22O23
  • Molecular Weight
    1900.17
  • CAS No.
    146340-20-7
  • Source
    Synthetic
  • Form
    Powder
  • Description
    Activated protein C (APC), a serine protease, regulates the blood coagulation pathway by inactivating the coagulation cofactors Va and VIIIa. Amino acid residues 390-404 in the APC heavy chain are essential for this anticoagulant activity. The corresponding synthetic peptide as well as anti-peptide antibodies specifically inhibit APC activity in several coagulation assays with half-maximal inhibition at 5 uM peptide and 30 nM antibody, respectively.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • R.M.Mesters et al., J. Biol. Chem., 266, 24514 (1991)
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Molecular Weight

Peptide Property

  • Analysed Sequence:H-YGVYTKVSRYLDWIH-OH
  • Chemical Formula:C91H130N22O23
  • Sequence length:15
  • Extinction coefficient:9530 M-1cm-1
  • GRAVY:-0.34
  • Mw average:1900.13
  • Theoretical pI:9.39
  • Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

X: Hydrophobic uncharged residues, like F I L M V W A and P

X: Basic residues, like R K H

X: Acidic residues, like D E

X: Polar uncharged residues, like G S T C N Q and Y

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"