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  • Semax peptide

Semax peptide

Not For Human Use, Lab Use Only.

Cat.#: 317047

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Product Information

  • Product Name
    Semax peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    MEHFPGP
  • Sequence
    H-Met-Glu-His-Phe-Pro-Gly-Pro-OH
  • Length (aa)
    7
  • Peptide Purity (HPLC)
    95.08%
  • Molecular Formula
    C37H51N9O10S
  • Molecular Weight
    813.92
  • CAS No.
    2828433-33-4
  • Source
    Synthetic
  • Form
    Powder
  • Description

    Semax, a synthetic heptapeptide (Met-Glu-His-Phe-Pro-Gly-Pro), is an ACTH-like analog known for its ability to form stable complexes with copper(II) ions. This peptide exhibits notable anti-aggregating properties, particularly in the presence of Cu2+, where it inhibits the formation of Aβ:Cu2+ complexes and interferes with fibrillogenesis. Semax modulates the interaction of amyloid-β peptides with lipid membranes, reducing membrane disruption and stabilizing oligomeric species. Its structural characteristics enable it to influence the aggregation pathways of amyloidogenic peptides, making it a subject of interest in studies of peptide-metal interactions and amyloid formation.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Shevchenko KV, Nagaev IIu, Alfeeva LIu, Andreeva LA, Kamenskiĭ AA, Levitskaia NG, Shevchenko VP, Grivennikov IA, Miasoedov NF [Kinetics of Semax penetration into the brain and blood of rats after its intranasal administration] Bioorg Khim 2006 Jan-Feb;32(1):64-70 Russian
    • Sciacca MFM, Naletova I, Giuffrida ML, Attanasio F. Semax, a Synthetic Regulatory Peptide, Affects Copper-Induced Abeta Aggregation and Amyloid Formation in Artificial Membrane Models. ACS Chem Neurosci. 2022 Feb 16;13(4):486-496. doi: 10.1021/acschemneuro.1c00707. Epub 2022 Jan 26. PMID: 35080861; PMCID: PMC8855339.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"