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  • ACTH (1-17), human peptide

ACTH (1-17), human peptide

Not For Human Use, Lab Use Only.

Cat.#: 310609

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* Buy 1 get 1 free (?) What is TFA?

Special Price 215.00 USD

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Product Information

  • Product Name
    ACTH (1-17), human peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    SYSMEHFRWGKPVGKKR
  • Sequence
    Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg
  • Length (aa)
    17
  • Peptide Purity (HPLC)
    96.4%
  • Molecular Formula
    C95H145N29O23S
  • Molecular Weight
    2093.5
  • CAS No.
    7266-47-9
  • Source
    Synthetic
  • Form
    Powder
  • Description

    ACTH (1-17), human, is a synthetic heptadecapeptide derived from the N-terminal segment of adrenocorticotropic hormone (ACTH). This peptide fragment has been studied for its potential role in modulating growth hormone (GH) secretion. In vitro experiments using primary cultures of rat anterior pituitary cells demonstrated that ACTH (1-17) induces only a slight, non-significant increase in GH secretion, even at micromolar concentrations. Similarly, no significant stimulatory effect was observed in human pituitary adenoma cells.

    The biological activity of ACTH (1-17) appears to be distinct from its parent molecule, as it lacks the direct pituitary-stimulating effects typically associated with full-length ACTH. Its mechanism of action may involve interactions with the central nervous system rather than direct pituitary regulation. Further research is needed to elucidate its precise physiological role and signaling pathways.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Ceda GP, Denti L, Valenti G. The effects of ACTH 1-17 on GH secretion in vitro. Horm Metab Res. 1987 Aug;19(8):361-3. doi: 10.1055/s-2007-1011824. PMID: 2822561.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"