Recombinant ACBD6 protein (His tag)

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Recombinant Human ACBD6 (37-282) is a high-purity protein fragment that encompasses the complete acyl-CoA-binding domain (ACB). This product enables researchers to study the specific molecular interactions of ACBD6 with long-chain acyl-coenzyme A molecules, particularly unsaturated C18:1-CoA, in a purified system. The fragment serves as an ideal tool for investigating protein N-myristoylation mechanisms and lipid-binding specificity.

Acyl-CoA-binding domain-containing protein 6 (ACBD6) is a human protein that selectively binds long-chain acyl-coenzyme A molecules, demonstrating strong preference for unsaturated C18:1-CoA, moderate affinity for unsaturated C20:4-CoA, and minimal binding to saturated C16:0-CoA. Notably, ACBD6 does not interact with free fatty acids. Recent research has established its crucial role in protein N-myristoylation, a key post-translational modification process. The protein localizes to both the cytoplasm and nucleus, suggesting potential regulatory functions in multiple cellular compartments. ACBD6's specific binding characteristics make it an important player in lipid metabolism and protein modification pathways.