|Fz7-21, a peptide antagonist for FZD7 receprotr subclass|
|Three letter code||(Ac)-Leu-Pro-Ser-Asp-Asp-Leu-Glu-Phe-Trp-Cys-His-Val-Met-Tyr-NH2|
|Peptide Purity (%)||95.3|
|Additional Information||The Fz7-21 (amino acid sequence: acetyl (Ac)-Leu-Pro-Ser-Asp-Asp-Leu-Glu-Phe-Trp-Cys-His-Val-Met-Tyr-NH2), impaired Wnt–β-catenin signaling in HEK293 cells that were stimulated with exogenous WNT3A or transfected with a construct expressing WNT3A or WNT1; it also blocked WNT3A-mediated stabilization of β -catenin in mouse L cells20 (IC50 = 50 nM), although the maximum inhibition reached a plateau at 50%. The observed difference in maximum Wnt pathway inhibition between HEK293 and mouse L cells, as measured by a Wnt-dependent luciferase reporter and β -catenin imaging assays, respectively, could likely be due to differences in cell surface expression levels of various FZD receptors across different cell lines.|
|Storage Guidelines||Ideally Fz7-21, a peptide antagonist for FZD7 receprotr subclass should be stored in a freezer at or below -9C. Fz7-21, a peptide antagonist for FZD7 receprotr subclass should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides|
|Terms||Please do not use the peptide for human consumption. NovoPro will immediately deny any order that we feel will be used outside of the scope of its intended purpose.|
Nile AH, de Sousa E Melo F, Mukund S, et al. A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nat Chem Biol. 2018
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