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catalog peptide: Fz7-21, a peptide antagonist for FZD7 receprotr subclass

Fz7-21, a peptide antagonist for FZD7 receprotr subclass

Cat.#: 318731

Special Price 120.0 USD

Availability: 1-2 weeks

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Description
Fz7-21, a peptide antagonist for FZD7 receprotr subclass
Quantity/Unit 1 Vial
Sequence Ac-LPSDDLEFWCHVMY-NH2
Three letter code (Ac)-Leu-Pro-Ser-Asp-Asp-Leu-Glu-Phe-Trp-Cys-His-Val-Met-Tyr-NH2
Length 14
Peptide Purity (%) 95.3
Molecular Formula C83H114N18O23S2
Molecular Weight 1796.02
Source Synthetic
Additional Information The Fz7-21 (amino acid sequence: acetyl (Ac)-Leu-Pro-Ser-Asp-Asp-Leu-Glu-Phe-Trp-Cys-His-Val-Met-Tyr-NH2), impaired Wnt–β-catenin signaling in HEK293 cells that were stimulated with exogenous WNT3A or transfected with a construct expressing WNT3A or WNT1; it also blocked WNT3A-mediated stabilization of β -catenin in mouse L cells20 (IC50 = 50 nM), although the maximum inhibition reached a plateau at 50%. The observed difference in maximum Wnt pathway inhibition between HEK293 and mouse L cells, as measured by a Wnt-dependent luciferase reporter and β -catenin imaging assays, respectively, could likely be due to differences in cell surface expression levels of various FZD receptors across different cell lines.
Storage Guidelines Ideally Fz7-21, a peptide antagonist for FZD7 receprotr subclass should be stored in a freezer at or below -9C. Fz7-21, a peptide antagonist for FZD7 receprotr subclass should be refrigerated after reconstitution. For more details, please refer to the manual:Handling and Storage of Synthetic Peptides
Terms Please do not use the peptide for human consumption. NovoPro will immediately deny any order that we feel will be used outside of the scope of its intended purpose.
References

Nile AH, de Sousa E Melo F, Mukund S, et al. A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nat Chem Biol. 2018

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