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  • Ac-DEVD-pNA peptide

Ac-DEVD-pNA peptide

Not For Human Use, Lab Use Only.

Cat.#: 319651

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* Buy 1 get 1 free (?) What is TFA?

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Product Information

  • Product Name
    Ac-DEVD-pNA peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    Ac-DEVD-pNA
  • Sequence
    Ac-Asp-Glu-Val-Asp-pNA
  • Length (aa)
    4
  • Peptide Purity (HPLC)
    95.44%
  • Molecular Formula
    C26H34N6O13
  • Molecular Weight
    638.58
  • CAS No.
    189950-66-1
  • PubChem CID
    11527474
  • Source
    Synthetic
  • Form
    Powder
  • Description
    The preferred chromogenic substrate for caspase-7 was Ac-DEVD-pNA. Caspase-3 also efficiently cleaved this peptide. Ac-DEVD-pNA was poorly cleaved by caspase-2. The chromogenic tetrapeptide P-nitroanilides Ac-YEVD-pNA and Ac-LEVD-pNA were preferentially cleaved by caspase-1 and-4, respectively, with higher kcat / Km values than related peptides, including the widely used substrate Ac-YVAD-pNA.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Talanian RV, Quinlan C, Trautz S, Hackett MC, Mankovich JA, Banach D, Ghayur T, Brady KD, Wong WW. Substrate specificities of caspase family proteases. J Biol Chem. 1997 Apr 11;272(15):9677-82. doi: 10.1074/jbc.272.15.9677. PMID: 9092497.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"