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  • AADvac 1 / Tau Peptide (294-305)-KLH

AADvac 1 / Tau Peptide (294-305)-KLH

Not For Human Use, Lab Use Only.

Cat.#: 319874

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* Buy 1 get 1 free (?) What is TFA?

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Product Information

  • Product Name
    AADvac 1 / Tau Peptide (294-305)-KLH
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    CKDNIKHVPGGGS, KLH conjugated
  • Sequence
    Lys-Asp-Asn-Ile-Lys-His-Val-Pro-Gly-Gly-Gly-Ser, KLH conjugated
  • Length (aa)
    12
  • Peptide Purity (HPLC)
    96%
  • Molecular Formula
    C51H85N17O17
  • Molecular Weight
    1208.343
  • CAS No.
    2307465-24-1
  • Source
    Synthetic
  • Form
    Powder
  • Description

    AADvac 1 is a peptide-based immunogen derived from the tau protein sequence 294-305(KDNIKHVPGGGS). This peptide encompasses the structural determinant 299-304 (HVPGGG), which is identified as a regulatory domain essential for pathological tau-tau interaction and oligomerization. The peptide is conjugated via an N-terminal cysteine residue to the carrier protein keyhole limpet haemocyanin (KLH) to form the immunogen Tau Peptide (294-305)-KLH.

    The immunogen is designed to target a specific, immunologically distinct structural determinant on mis-disordered tau protein. This determinant is revealed by monoclonal antibody DC8E8 and represents a region critical for tau misfolding. The construct aims to elicit a humoral immune response against this particular epitope, with generated antibodies demonstrating the ability to discriminate between pathological and physiological tau forms.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Kontsekova E, Zilka N, Kovacech B, Novak P, Novak M. First-in-man tau vaccine targeting structural determinants essential for pathological tau-tau interaction reduces tau oligomerisation and neurofibrillary degeneration in an Alzheimer's disease model. Alzheimers Res Ther. 2014 Aug 1;6(4):44. doi: 10.1186/alzrt278. PMID: 25478017; PMCID: PMC4255368.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"