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  • 8DSS peptide

8DSS peptide

Not For Human Use, Lab Use Only.

Cat.#: 319865

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* Buy 1 get 1 free (?) What is TFA?

Special Price 220.50 USD

Availability: 3 weeks
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Product Information

  • Product Name
    8DSS peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    DSSDSSDSSDSSDSSDSSDSSDSS
  • Sequence
    Asp-Ser-Ser-Asp-Ser-Ser-Asp-Ser-Ser-Asp-Ser-Ser-Asp-Ser-Ser-Asp-Ser-Ser-Asp-Ser-Ser-Asp-Ser-Ser
  • Length (aa)
    24
  • Peptide Purity (HPLC)
    97%
  • Molecular Formula
    C80H122N24O57
  • Molecular Weight
    2331.967
  • Source
    Synthetic
  • Form
    Powder
  • Description

    The 8DSS peptide is a synthetic oligopeptide consisting of eight tandem repeats of the aspartate-serine-serine (DSS) amino acid sequence. This sequence is the fundamental repetitive unit found within dentin phosphoprotein (DPP), a non-collagenous protein that plays a critical role in the biomineralization process of dentin. The peptide is characterized by its molecular weight of approximately 2331.4 Da and contains multiple negatively charged amino acid residues.

    In vitro studies demonstrate that the 8DSS peptide exhibits a strong binding affinity to demineralized type I collagen matrices, primarily through electrostatic interactions. When applied to such substrates in a mineralizing solution, the peptide functions as a nucleation template, promoting the precipitation and growth of hydroxyapatite nanocrystals. These newly formed minerals deposit on the collagen fibril surfaces and within dentinal tubules, leading to microstructural restoration and a significant improvement in the nano-mechanical properties, such as hardness and elastic modulus, of the treated substrate.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Liang K , Xiao S , Shi W , Li J , Yang X , Gao Y , Gou Y , Hao L , He L , Cheng L , Xu X , Zhou X , Li J . 8DSS-promoted remineralization of demineralized dentin in vitro. J Mater Chem B. 2015 Sep 7;3(33):6763-6772. doi: 10.1039/c5tb00764j. Epub 2015 Jul 29. PMID: 32262469.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"