7w-2 peptide

7w-2 peptide

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-SFHFGRL-OH

H-Ser-Phe-His-Phe-Gly-Arg-Leu-OH

7

95.53%

C₄₁H₅₈N₁₂O₉

862.97

Synthetic

Powder

7w-2 is a novel peptide that targets GPR81 to suppress adipocyte-mediated tumor progression. It has been found to induce the internalization of GPR81 on the cell membrane, similar to NaL. 7w-2 exhibits a dose-dependent reduction in intracellular cAMP content, indicating its potential role as a GPR81 agonist capable of modulating intracellular cAMP levels. The bioactivity of 7w-2 has been evaluated through a receptor internalization assay, where it demonstrated a pronounced ability to induce the internalization of GPR81 on the cell membrane.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Chen S, Zhou X, Li W, Yang X, Niu X, Hu Z, Li S, Chen G, Sui X, Liu J, Gao Y. Development of a novel peptide targeting GPR81 to suppress adipocyte-mediated tumor progression. Biochem Pharmacol. 2023 Sep 9:115800. doi: 10.1016/j.bcp.2023.115800. Epub ahead of print. PMID: 37696459.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.