736-745-TAT peptide

736-745-TAT peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-KDDYRWCFRVYGRKKRRQRRR-OH

H-Lys-Asp-Asp-Tyr-Arg-Trp-Cys-Phe-Arg-Val-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-OH

21

95.55%

C₁₂₇H₂₀₆N₅₀O₂₉S

2929.37

Synthetic

Powder

736-745-TAT, also known as TAT-TRPV1(736-745), is a cell permeable TRPV1 fragment that can inhibit the interaction of TRPV1 and AKAP79. 736-745-TAT consists of amino acids 736-749 from the TRPV1 C-terminal domain, combined with amino acids 47–57 of TAT to promote uptake across neuronal cell membranes. 736-745-TAT inhibits both the first and the second phase of pain behaviour in the formalin test, implying an effect on both acute and inflammatory pain.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Fischer et al (2013) Disrupting sensitization of transient receptor potential vanilloid subtype 1 inhibits inflammatory hyperalgesia. J. Neurosci. 33(17) 7407 PMID: 23616546

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.