18-CSP peptide

18-CSP peptide

• COA/MS/HPLC Report
• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-SGSLSTFFRLFNRSFTQA-OH

H-Ser-Gly-Ser-Leu-Ser-Thr-Phe-Phe-Arg-Leu-Phe-Asn-Arg-Ser-Phe-Thr-Gln-Ala-OH

18

95.37%

C₉₄H₁₄₀N₂₆O₂₇

2066.25

Synthetic

Powder

18-CSP is an 18 amino acid competence stimulating peptide. 18-CSP is derived from the ComC precursor, processed to a final length of 18 residues and exported to the extracellular medium. S. mutans detects CSP through the ComDE two-component signal transduction system (TCS), which directly activates multiple genes involved in bacteriocin biogenesis, secretion and immunity.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Son M, Kaspar J, Ahn SJ, Burne RA, Hagen SJ. Threshold regulation and stochasticity from the MecA/ClpCP proteolytic system in Streptococcus mutans competence. Mol Microbiol. 2018 Dec;110(6):914-930. doi: 10.1111/mmi.13992. Epub 2018 Nov 11. PMID: 29873131; PMCID: PMC6281771.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.