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  • 11R-VIVIT peptide

11R-VIVIT peptide

Not For Human Use, Lab Use Only.

Cat.#: 319810

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* Buy 1 get 1 free (?) What is TFA?

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Product Information

  • Product Name
    11R-VIVIT peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-RRRRRRRRRRRGGGMAGPHPVIVITGPHEE-OH
  • Sequence
    H-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Gly-Gly-Gly-Met-Ala-Gly-Pro-His-Pro-Val-Ile-Val-Ile-Thr-Gly-Pro-His-Glu-Glu-OH
  • Length (aa)
    30
  • Peptide Purity (HPLC)
    95.69%
  • Molecular Formula
    C147H259N67O36S
  • Molecular Weight
    3573.11
  • CAS No.
    592517-80-1
  • Source
    Synthetic
  • Form
    Powder
  • Description

    The 11R-VIVIT peptide is a cell-permeable inhibitor of the nuclear factor of activated T-cells (NFAT), specifically targeting the calcineurin-NFAT interaction. This peptide selectively interferes with NFAT activation without affecting calcineurin phosphatase activity. In podocytes, 11R-VIVIT has been shown to inhibit high glucose-induced NFAT2 nuclear accumulation, thereby reducing downstream signaling pathways associated with cellular injury. The peptide also attenuates the expression of urokinase-type plasminogen activator receptor (uPAR), a protein linked to podocyte dysfunction. These effects highlight the role of 11R-VIVIT in modulating the calcineurin/NFAT2/uPAR signaling axis, which is implicated in maintaining podocyte integrity under pathological conditions.

  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Zhang L, Li R, Shi W, Liang X, Liu S, Ye Z, Yu C, Chen Y, Zhang B, Wang W, Lai Y, Ma J, Li Z, Tan X. NFAT2 inhibitor ameliorates diabetic nephropathy and podocyte injury in db/db mice. Br J Pharmacol. 2013 Sep;170(2):426-39. doi: 10.1111/bph.12292. PMID: 23826864; PMCID: PMC3834765.
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"