(pGlu-Gln)-CCK-8 peptide

(pGlu-Gln)-CCK-8 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

Pyr-QDY(SO3H)MGWMDF-NH2

H-pGlu-Gln-Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2

10

95.12%

C₅₉H₇₅N₁₃O₂₀S₃

1382.49

Synthetic

Powder

(pGlu-Gln)-CCK-8 is a novel cholecystokinin agonist, a synthetic peptide analogue of CCK-8. It acts as a pancreatic beta cell growth factor and anti-apoptotic agent, similar to incretin hormones GLP-1 and GIP. (pGlu-Gln)-CCK-8 stimulates insulin release and inhibits food intake in a concentration-dependent manner. The peptide shows promise for treating obesity and diabetes due to its metabolic stability and in vitro biological activity. (pGlu-Gln)-CCK-8 exerts its effects through CCK1 receptor activation, leading to satiety and reduced food intake.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Irwin N, Pathak V, Flatt PR. A Novel CCK-8/GLP-1 Hybrid Peptide Exhibiting Prominent Insulinotropic, Glucose-Lowering, and Satiety Actions With Significant Therapeutic Potential in High-Fat-Fed Mice. Diabetes. 2015 Aug;64(8):2996-3009. doi: 10.2337/db15-0220. Epub 2015 Apr 16. Erratum in: Diabetes. 2016 Apr;65(4):1120. PMID: 25883113.
• Irwin N, Frizelle P, Montgomery IA, Moffett RC, O'Harte FPM, Flatt PR. Beneficial effects of the novel cholecystokinin agonist (pGlu-Gln)-CCK-8 in mouse models of obesity/diabetes. Diabetologia. 2012 Oct;55(10):2747-2758. doi: 10.1007/s00125-012-2654-6. Epub 2012 Jul 20. PMID: 22814764.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.