γ-Glu-Phe peptide

γ-Glu-Phe peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

γ-EF

H-γGlu-Phe-OH

2

95.9%

C₁₄H₁₈N₂O₅

294.3

7432-24-8

111299

Synthetic

Powder

γ-Glu-Phe, or gamma-glutamyl-phenylalanine, is a dipeptide consisting of two amino acids, glutamic acid (Glu) and phenylalanine (Phe). In this peptide, the carboxyl group of the glutamic acid forms a peptide bond with the amino group of the phenylalanine. γ-Glu-Phe is known for its savory, or umami, taste. It contributes to the overall flavor of certain foods, enhancing their taste without adding additional salt. This dipeptide can be found in various fermented foods, such as cheese and soy sauce, where it is formed through microbial activity and enzymatic reactions during the fermentation process. The presence of γ-Glu-Phe and other γ-glutamyl dipeptides in foods can contribute to a more complex and satisfying taste experience, which is particularly important in low-salt or reduced-fat food products where the perception of saltiness or richness may be diminished.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Zhao CJ, Gänzle MG. Synthesis of Taste-Active γ-Glutamyl Dipeptides during Sourdough Fermentation by Lactobacillus reuteri. J Agric Food Chem. 2016 Oct 12;64(40):7561-7568. doi: 10.1021/acs.jafc.6b02298. Epub 2016 Sep 29. PMID: 27641253.

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.