[D-Lys3]-GHRP-6 peptide

[D-Lys3]-GHRP-6 peptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

H-HwkWfK-NH2 (Trp-2 = D-Trp, Lys-3 = D-Lys, Phe-5 = D-Phe)

H-His-Trp-Lys-Trp-Phe-Lys-NH2 (Trp-2 = D-Trp, Lys-3 = D-Lys, Phe-5 = D-Phe)

6

95.43%

C₄₉H₆₃N₁₃O₆

930.11

Synthetic

Powder

[D-Lys3]-GHRP-6 is a ghrelin receptor (GHS-R1a) antagonist which also binds weakly to melanocortin receptors. [D-Lys3]-GHRP-6 can decrease energy intake in lean mice, mice with diet induced obesity, and in ob/ob obese mice, and reduces the rate of gastric emptying. [D-Lys3]-GHRP-6 also blocks or reduces ethanol intake and reward seeking in animal models.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Schioth et al (1997) Characterization of the binding of MSH-B, HP-228, GHRP-6 and 153N-6 to the human melanocortin receptor subtypes. Neuropeptides 31 565 PMID: 9574823
• Gomez and Ryabinin (2014) The effects of ghrelin antagonists [D-Lys(3) ]-GHRP-6 or JMV2959 on ethanol, water, and food intake in C57BL/6J mice. Alcohol Clin Exp Res. 38(9) 2436 PMID: 25257292
• Mosa et al (2018) Long-term treatment with the ghrelin receptor antagonist [d-Lys3]-GHRP-6 does not improve glucose homeostasis in nonobese diabetic MKR mice. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 314(1) R71 PMID: 28903914

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.