[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic polypeptide

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic polypeptide

• Handling and Storage of Synthetic Peptides
• Material Safety Data Sheets (MSDS)

Batch to batch variation of the purity

GPSQPTYPGDNATPEQMARYYSALRRYINMAXRQRY-NH2, X = Aib

H-Gly-Pro-Ser-Gln-Pro-Thr-Tyr-Pro-Gly-Asp-Asn-Ala-Thr-Pro-Glu-Gln-Met-Ala-Arg-Tyr-Tyr-Ser-Ala-Leu-Arg-Arg-Tyr-Ile-Asn-Met-Ala-Aib-Arg-Gln-Arg-Tyr-NH2

36

95.25%

C₁₈₃H₂₈₁N₅₇O₅₄S₂

4207.67

Synthetic

Powder

[cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide is a potent and selective peptide agonist for the neuropeptide Y Y5 receptor , with IC50 values for inhibition of neuropeptide Y binding to human Y5, Y1, Y2 and Y4 receptors of 0.24, 530, > 500, and 51 nM respectively, and a Ki at Y5 of 0.1 - 0.15 nM. [cPP1-7,NPY19-23,Ala31,Aib32,Gln34] - hPancreatic Polypeptide stimulates food intake in vivo.

Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• Cabrele et al (2000) The first selective agonist for the neuropeptide YY5 receptor increases food intake in rats. J.Biol.Chem. 275 36043 PMID: 10944518
• Quarta et al (2011) Central administration of NPY or an NPY-Y5 selective agonist increase in vivo extracellular monoamine levels in mesocorticolimbic projecting areas. Neuropharmacology 60(2-3) 328 PMID: 20868698
• Medeiros and Jackson (2013) Neuropeptide Y Y5-receptor activation on breast cancer cells acts as a paracrine system that stimulates VEGF expression and secretion to promote angiogenesis. Peptides 48 106 PMID: 23932937

Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.