Cart 2
  • [Ala11,D-Leu15]-Orexin B peptide

[Ala11,D-Leu15]-Orexin B peptide

Not For Human Use, Lab Use Only.

Cat.#: 319067

Size:

* Buy 1 get 1 free (?) What is TFA?

Special Price 237.90 USD

Availability: 3 weeks
- +

Add to cart to get an online quotation

Product Information

  • Product Name
    [Ala11,D-Leu15]-Orexin B peptide
  • Documents

    Batch to batch variation of the purity

  • Sequence Shortening
    H-RSGPPGLQGRAQRLLQASGNHAAGILTM-NH2
  • Sequence
    H-Arg-Ser-Gly-Pro-Pro-Gly-Leu-Gln-Gly-Arg-Ala-Gln-Arg-Leu-Leu-Gln-Ala-Ser-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Met-NH2
  • Length (aa)
    28
  • Peptide Purity (HPLC)
    95.94%
  • Molecular Formula
    C120H206N44O35S
  • Molecular Weight
    2857.24
  • Source
    Synthetic
  • Form
    Powder
  • Description
    [Ala11,D-Leu15]-Orexin B is a highly potent and selective OX2 receptor agonist with 400-fold selectivity for OX2 over OX1 receptors, possessing EC50 values of 0.13 and 52 nM for human OX2 and OX1 receptors respectively. [Ala11,D-Leu15]-Orexin B increases social novelty seeking and can decrease anxious and depressive behaviour in animal models.
  • Storage Guidelines
    Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides
  • References
    • Asahi et al (2003) Development of an orexin-2 receptor selective agonist, [Ala11D-Leu15]orexin-B. Bioorg.Med.Chem.Lett. 13 111 PMID: 12467628
    • Borgland et al (2008), Orexin B/hypocretin 2 increases glutamatergic transmission to ventral tegmental area neurons. European J. Neuroscience 28 1545 PMID: 18793323
    • Staton et al (2018) Orexin 2 receptor stimulation enhances resilience, while orexin 2 inhibition promotes susceptibility, to social stress, anxiety and depression, Neuropharmacology 143 79 PMID: 30240784
  • About TFA salt

    Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

    Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

    Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

    In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

  • Molar Concentration Calculator

  • Dilution Calculator

  • Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"