Anti-YB1 Rabbit antibody

Cat.#: 167251

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Special Price 441.3 USD

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Product Information

  • Product Name
    Anti-YB1 Rabbit antibody
  • Documents
  • Description
    YB1 Rabbit polyclonal antibody
  • Tested applications
    WB, FC, IP
  • Species reactivity
    Human
  • Alternative names
    YB1; BP-8; CSDB; DBPB; YB-1; CBF-A; CSDA2; EFI-A; NSEP1; NSEP-1; MDR-NF1 antibody
  • Isotype
    Rabbit IgG
  • Preparation
    Antigen: A synthetic peptide of human YB1
  • Clonality
    Polyclonal
  • Formulation
    Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
  • Storage instructions
    Store at -20°C. Stable for 12 months from date of receipt.
  • Applications

    WB: 1/1000-1/5000

    FC: 1/20

    IP: 1/20

  • Validations

    Western blot detection of YB1 in Hela cell lysates using YB1 Rabbit pAb(1:1000 diluted).Predicted band size:36kDa.Observed band size:49kDa.

    Western blot detection of YB1 in Hela cell lysates using YB1 Rabbit pAb(1:1000 diluted).Predicted band size:36kDa.Observed band size:49kDa.

  • Background
    Swiss-Prot Acc.P67809.Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors . Regulates the transcription of numerous genes. Its transcriptional activity on the multidrug resistance gene MDR1 is enhanced in presence of the APEX1 acetylated form at 'Lys-6' and 'Lys-7'. Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as MDR1 and HLA class II genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability. Binds preferentially to the 5'-[CU]CUGCG-3' motif in vitro.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"