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Product Name
Anti-phospho-FAK (Tyr576) Rabbit antibody
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Description
phospho-FAK (Tyr576) Rabbit monoclonal antibody
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Tested applications
WB, FC
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Species reactivity
Human, Mouse, Rat
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Isotype
IgG
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Preparation
Antigen: A synthetic phosphopeptide corresponding to residues surrounding Tyr576 of human FAK
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Clonality
Monoclonal
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Formulation
50nM Tris-Glycine(pH 7.4), 0.15M NaCl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA
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Storage instructions
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
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Applications
WB: 1/2000-1/10000
FC: 1/20
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Validations
Western blot detection of phospho-FAK (Tyr576) in A549,U251,C2C12 cell lysates using phospho-FAK (Tyr576) Rabbit mAb(1:1000 diluted).Predicted band size:119kDa.Observed band size:125kDa.
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Background
This gene encodes a cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017]
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"