Canine BLyS/TNFSF13B (Fc Tag) recombinant protein

Cat.#: 502837

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Product Information

  • Product Name
    Canine BLyS/TNFSF13B (Fc Tag) recombinant protein
  • Documents
  • Description
    B lymphocyte stimulator (BLyS), also known as TNFSF13B, CD257 and BAFF, is single-pass type II membrane protein, which belongs to the tumor necrosis factor family. BAFF is abundantly expressed in peripheral blood Leukocytes and is specifically expressed in monocytes and macrophages. BAFF is a cytokine and serves as a ligand for receptors TNFRSF13B (TACI), TNFRSF17 (BCMA), and TNFRSF13C (BAFFR). These receptors is a prominent factor in B cell differentiation, homeostasis, and selection. BLyS levels affect survival signals and selective apoptosis of autoantibody-producing B cells. Thus, it acts as a potent B cell activator and has been shown to play an important role in the proliferation and differentiation of B cells. Overexpression of BLyS in mice can lead to clinical and serological features of systemic lupus erythematosus (SLE) and Sjögren's syndrome (SS). BLyS as an attractive therapeutic target in human rheumatic diseases. The ability of BLyS to regulate both the size and repertoire of the peripheral B cell compartment raises the possibility that BLyS and antagonists thereof may form the basis of a therapeutic trichotomy. As an agonist, BLyS protein may enhance humoral immunity in congenital or acquired immunodeficiencies such as those resulting from viral infection or cancer therapy.
  • Protein name
    Tumor necrosis factor superfamily member 13b
  • Protein short names
    D8ERTD387E; TNFSF20; BLYS; ZTNF4; MGC124061; TALL-1; DTL; BAFF; MGC124060; CD257; THANK; TALL1; TNFSF13B
  • Uniprot ID
    C4NZX1
  • Source/Expression Host
    Human Cells
  • Expression Plasmid/cDNA
    A DNA sequence encoding the canine TNFSF13B (NP_001155182.1) (Ala143-Leu292) was expressed with the Fc region of human IgG1 at the N-terminus.
  • Protein Species
    Canine
  • Molecular weight
    The recombinant canine TNFSF13B consists 412 amino acids and predicts a molecular mass of 45.5 kDa.
  • Purity
    > 90 % as determined by SDS-PAGE.
  • Validations

    TNFSF13B protein SDS-PAGE

    TNFSF13B protein SDS-PAGE

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"