TBP antibody

TBP antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

TBP Mouse Monoclonal antibody. Positive IHC detected in human breast cancer tissue, human liver cancer tissue. Positive IP detected in HEK-293 cells. Positive WB detected in HEK-293 cells, pig liver tissue. Observed molecular weight by Western-blot: 40 kDa

ELISA, WB, IP, IHC

Human, Mouse, Rat, Pig; other species not tested.

GTF2D antibody; GTF2D1 antibody; SCA17 antibody; TATA binding factor antibody; TATA box binding protein antibody; TATA box factor antibody; TATA sequence binding protein antibody; TBP antibody; TF2D antibody; TFIID antibody

Mouse IgG2a

This antibody was obtained by immunization of TBP recombinant protein (Accession Number: NM_003194). Purification method: Protein A purified.

Monoclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

The TATA binding protein (TBP) is a transcription factor that binds specifically to a DNA sequence TATA box. This DNA sequence is found about 25-30 base pairs upstream of the transcription start site in some eukaryotic gene promoters. TBP, along with a variety of TBP-associated factors, make up the TFIID, a general transcription factor that in turn makes up part of the RNA polymerase II preinitiation complex. As one of the few proteins in the preinitation complex that binds DNA in a sequence-specific manner, it helps position RNA polymerase II over the transcription start site of the gene. However, it is estimated that only 10-20% of human promoters have TATA boxes. Therefore, TBP is probably not the only protein involved in positioning RNA polymerase II. This antibody detects human TBP (~40 kDa) and mouse/rat Tbp (~35 kDa).

• Li D, Wang X, Lan X. Down-regulation of miR-144 elicits proinflammatory cytokine production by targeting toll-like receptor 2 in nonalcoholic steatohepatitis of high-fat-diet-induced metabolic syndrome E3 rats. Molecular and cellular endocrinology. 402:1-12. 2015.