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STOML2 antibody

Cat.#: 115731

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Product Information

  • Product Name
    STOML2 antibody
  • Documents
  • Description
    STOML2 Rabbit Polyclonal antibody. Positive IF detected in MCF-7 cells. Positive IHC detected in human lung cancer tissue, human breast cancer tissue, human endometrial cancer tissue. Positive WB detected in C6 cells, mouse brain tissue. Positive IP detected in mouse brain tissue. Observed molecular weight by Western-blot: 39 kDa
  • Tested applications
    ELISA, IF, IP, WB, IHC
  • Species reactivity
    Human,Mouse,Rat; other species not tested.
  • Alternative names
    EPB72 like protein 2 antibody; HSPC108 antibody; SLP 2 antibody; SLP2 antibody; stomatin (EPB72) like 2 antibody; Stomatin like protein 2 antibody; STOML2 antibody
  • Immunogen
    Human STOML2 Recombinant protein (GST tag)
  • Isotype
    Rabbit IgG
  • Preparation
    This antibody was obtained by immunization of STOML2 recombinant protein (Accession Number: NM_013442). Purification method: Antigen affinity purified.
  • Clonality
    Polyclonal
  • Formulation
    PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
  • Storage instructions
    Store at -20℃. DO NOT ALIQUOT
  • Applications

    Recommended Dilution:

    WB: 1:500-1:5000

    IP: 1:500-1:5000

    IHC: 1:20-1:200

    IF: 1:20-1:200

  • Validations

    Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:115731(STOML2 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:115731(STOML2 antibody) at dilution of 1:100 (under 10x lens)

    Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:115731(STOML2 antibody) at dilution of 1:100 (under 40x lens)

    Immunohistochemical of paraffin-embedded human lung cancer using Catalog No:115731(STOML2 antibody) at dilution of 1:100 (under 40x lens)

    Immunofluorescent analysis of MCF-7 cells, using STOML2 antibody Catalog No:115731 at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

    Immunofluorescent analysis of MCF-7 cells, using STOML2 antibody Catalog No:115731 at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

    IP Result of anti-STOML2 (IP:Catalog No:115731, 3ug; Detection:Catalog No:115731 1:1000) with mouse brain tissue lysate 1000ug.

    IP Result of anti-STOML2 (IP:Catalog No:115731, 3ug; Detection:Catalog No:115731 1:1000) with mouse brain tissue lysate 1000ug.

    C6 cells were subjected to SDS PAGE followed by western blot with Catalog No:115731(STOML2 Antibody) at dilution of 1:1000

    C6 cells were subjected to SDS PAGE followed by western blot with Catalog No:115731(STOML2 Antibody) at dilution of 1:1000

  • Background
    STOML2 (Stomatin-like protein 2; also known as SLP-2) is a widely expressed mitochondrial member of the highly conserved family of stomatin proteins. STOML2 is localized mostly in mitochondrial inner membrane, minor in plasma membrane. Human STOML2 interacts with prohibitins and regulates mitochondrial biogenesis and function (21746876). In addition, plenty of studies revealed that STOML2 was overexpressed in many human cancer tissues, and its expression may be a new valuable prognostic biomarker (19839737, 21960069). Recently STOML2 has been identified as a serological biomarker for early colorectal cancer (CRC) diagnosis (21209152).
  • References
    • Kirchhof MG, Chau LA, Lemke CD. Modulation of T cell activation by stomatin-like protein 2. Journal of immunology (Baltimore, Md. : 1950). 181(3):1927-36. 2008.
    • Mitsopoulos P, Chang YH, Wai T. Stomatin-like protein 2 is required for in vivo mitochondrial respiratory chain supercomplex formation and optimal cell function. Molecular and cellular biology. 35(10):1838-47. 2015.
    • Richter-Dennerlein R, Korwitz A, Haag M. DNAJC19, a mitochondrial cochaperone associated with cardiomyopathy, forms a complex with prohibitins to regulate cardiolipin remodeling. Cell metabolism. 20(1):158-71. 2014.
    • Sun F, Ding W, He JH, Wang XJ, Ma ZB, Li YF. Stomatin-like protein 2 is overexpressed in epithelial ovarian cancer and predicts poor patient survival. BMC cancer. 15:746. 2015.
    • Bartolome A, Boskovic S, Paunovic I, Bozic V, Cvejic D. Stomatin-like protein 2 overexpression in papillary thyroid carcinoma is significantly associated with high-risk clinicopathological parameters and BRAFV600E mutation. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 2016.
    • Zhang L, Ding F, Cao W. Stomatin-like protein 2 is overexpressed in cancer and involved in regulating cell growth and cell adhesion in human esophageal squamous cell carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 12(5):1639-46. 2006.
    • Chang D, Ma K, Gong M. SLP-2 overexpression is associated with tumour distant metastasis and poor prognosis in pulmonary squamous cell carcinoma. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals. 15(2):104-10. 2010.
    • McCray BA, Skordalakes E, Taylor JP. Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation. Human molecular genetics. 19(6):1033-47. 2010.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"