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Product Name
STOML2 antibody
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Description
STOML2 Mouse Monoclonal antibody. Positive IHC detected in human endometrial cancer tissue, human lung cancer tissue. Positive WB detected in HepG2 cells, human heart tissue. Positive IP detected in mouse brain tissue. Observed molecular weight by Western-blot: 39kd
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Tested applications
ELISA, WB, IHC, IP
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
EPB72 like protein 2 antibody; HSPC108 antibody; SLP 2 antibody; SLP2 antibody; stomatin (EPB72) like 2 antibody; Stomatin like protein 2 antibody; STOML2 antibody
- Immunogen
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Isotype
Mouse IgG2b
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Preparation
This antibody was obtained by immunization of STOML2 recombinant protein (Accession Number: NM_013442). Purification method: Caprylic acid/ammonium sulfate precipitation.
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Clonality
Monoclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IP: 1:500-1:5000
IHC: 1:20-1:200
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Validations
HepG2 cells were subjected to SDS PAGE followed by western blot with Catalog No:107610(STOML2 antibody) at dilution of 1:1000
Immunohistochemical of paraffin-embedded human endometrial cancer using Catalog No:107610(STOML2 antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human endometrial cancer using Catalog No:107610(STOML2 antibody) at dilution of 1:100 (under 40x lens)
IP Result of anti-STOML2 (IP:Catalog No:107610, 4ug; Detection:Catalog No:107610 1:1000) with mouse brain tissue lysate 4000ug.
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Background
Human stomatin (band 7.2b) is a 31-kDa erythrocyte membrane protein of unknown function but implicated in the control of ion channel permeability, mechanoreception, and lipid domain organization. Stomatin (EPB72)-like 2 (STOML2, synonyms: SLP-2, HSPC108) is a 38.5-kDa protein that is overall approximately 20% similar to human stomatin. STOML2 is also present in mature human erythrocytes , but lacks a characteristic NH(2)-terminal hydrophobic domain found in other stomatin homologues. STOML2 may link stomatin or other integral membrane proteins to the peripheral cytoskeleton and thereby play a role in regulating ion channel conductances or the organization of sphingolipid and cholesterol-rich lipid rafts.
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References
- Han CL, Chen JS, Chan EC. An informatics-assisted label-free approach for personalized tissue membrane proteomics: case study on colorectal cancer. Molecular & cellular proteomics : MCP. 10(4):M110.003087. 2011.
- Takadate T, Onogawa T, Fukuda T. Novel prognostic protein markers of resectable pancreatic cancer identified by coupled shotgun and targeted proteomics using formalin-fixed paraffin-embedded tissues. International journal of cancer. 132(6):1368-82. 2013.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"