STAT3 antibody

STAT3 antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

STAT3 Rabbit Polyclonal antibody. Positive IHC detected in human cervical cancer tissue, human breast cancer tissue, human lung cancer tissue. Positive IP detected in HeLa cells. Positive WB detected in HeLa cells, K-562 cells. Observed molecular weight by Western-blot: 88kd

ELISA, WB, IHC, IP

Human, Mouse; other species not tested.

Acute phase response factor antibody; APRF antibody; FLJ20882 antibody; HIES antibody; STAT3 antibody

Rabbit IgG

This antibody was obtained by immunization of Peptide (Accession Number: XM_017024975). Purification method: Antigen affinity purified.

Polyclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3, synonyms: APRF, FLJ20882, MGC16063) is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. STAT3 is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. STAT3 mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of STAT3. This antibody is a rabbit polyclonal antibody raised against a peptide mapping within human STAT3.

• Gao X, Wang JY, Gao LM, Yin XF, Liu L. Identification and analysis of glycogen synthase kinase 3 beta1 interactome. Cell biology international. 37(8):768-79. 2013.
• Hu X, Yu J, Zhou X. A small GTPase‑like protein fragment of Mycoplasma promotes tumor cell migration and proliferation in vitro via interaction with Rac1 and Stat3. Molecular medicine reports. 9(1):173-9. 2014.