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Product Name
SLC30A8/ZNT8-Specific antibody
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Description
SLC30A8/ZNT8-Specific Rabbit Polyclonal antibody. Positive IHC detected in human pancreas tissue, human liver cancer tissue. Positive WB detected in mouse pancreas tissue. Observed molecular weight by Western-blot: 45-50 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
SLC30A8 antibody; Zinc transporter 8 antibody; ZnT 8 antibody; ZNT8 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Peptide (Accession Number: NM_173851). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
mouse pancreas tissue were subjected to SDS PAGE followed by western blot with Catalog No:115365(SLC30A8-Specific antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human pancreas using Catalog No:115365(SLC30A8-Specific antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human pancreas using Catalog No:115365(SLC30A8-Specific antibody) at dilution of 1:50 (under 40x lens)
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Background
SLC30A8 (also named as ZNT8) encods the secretory granule zinc transporter, permiting cellular efflux of zinc. SLC30A8 was recently defined as a autoantigen candidates of type 2 diabetes, although the molecular mechanism through which this phenotype is manifest is incompletely understood.
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References
- Xu G, Kang D, Zhang C. Erythropoietin Protects Retinal Cells in Diabetic Rats Through Upregulating ZnT8 via Activating ERK Pathway and Inhibiting HIF-1α Expression. Investigative ophthalmology & visual science. 56(13):8166-78. 2015.
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