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Product Name
SCO2 antibody
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Description
SCO2 Rabbit Polyclonal antibody. Positive IHC detected in human heart tissue, human hepat℃irrhosis tissue. Positive WB detected in HEK-293 cells. Observed molecular weight by Western-blot: 27-30kd
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human, Mouse; other species not tested.
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Alternative names
SCO1L antibody; SCO2 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of SCO2 recombinant protein (Accession Number: NM_001169111). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:20-1:200
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Validations
HEK-293 cells were subjected to SDS PAGE followed by western blot with Catalog No:115013(SCO2 antibody) at dilution of 1:500
Immunohistochemical of paraffin-embedded human heart using Catalog No:115013(SCO2 antibody) at dilution of 1:50 (under 10x lens)
Immunohistochemical of paraffin-embedded human heart using Catalog No:115013(SCO2 antibody) at dilution of 1:50 (under 40x lens)
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Background
Human SCO2 is a mitochondrial membrane-bound protein involved in copper supply for the assembly of cytochrome c oxidase in eukaryotes.It is involved in the maintenance of cell copper homeostasis or, limited to HSco2, as a downstream mediator of the Warburg effect, as its expression is regulated by p53(PMID:17850752).This protein belongs to the SCO1/2 family and defects in SCO2 are the cause of fatal infantile cardioencephalomyopathy with cytochrome c oxidase deficiency (FIC).
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References
- Napoli E, Ross-Inta C, Wong S. Mitochondrial dysfunction in Pten haplo-insufficient mice with social deficits and repetitive behavior: interplay between Pten and p53. PloS one. 7(8):e42504. 2012.
- Liu F, Zhang W, You X. The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer. Oncotarget. 6(29):27199-213. 2015.
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