RXRA antibody

RXRA antibody

• DataSheet
• Material Safety Data Sheets (MSDS)

RXRA Mouse Monoclonal antibody. Positive WB detected in Hela cells. Observed molecular weight by Western-blot: 44 kDa

ELISA, WB

Human,Mouse; other species not tested.

FLJ00280 antibody; FLJ00318 antibody; FLJ16020 antibody; FLJ16733 antibody; NR2B1 antibody; Retinoid X receptor alpha antibody; retinoid X receptor antibody; alpha antibody; RXRA antibody

Mouse IgG1

This antibody was obtained by immunization of RXRA recombinant protein (Accession Number: BC007925). Purification method: Protein G purified.

Monoclonal

PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Store at -20℃. DO NOT ALIQUOT

Retinoid X receptor alpha (RXRA). Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes.