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Product Name
Prealbumin/transthyretin antibody
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Description
Prealbumin/transthyretin Rabbit Polyclonal antibody. Positive IHC detected in human liver cancer tissue, human gliomas tissue. Positive WB detected in human blood tissue, HEK-293 cells, human brain tissue, human heart tissue, human liver tissue, human spleen tissue. Observed molecular weight by Western-blot: 16kd
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human; other species not tested.
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Alternative names
ATTR antibody; HsT2651 antibody; PALB antibody; Prealbumin antibody; TBPA antibody; transthyretin antibody; TTR antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of Prealbumin/transthyretin recombinant protein (Accession Number: NM_000371). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:500-1:5000
IHC: 1:20-1:200
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Validations
human blood tissue were subjected to SDS PAGE followed by western blot with Catalog No:114179(TTR antibody) at dilution of 1:1000
Immunohistochemical of paraffin-embedded human liver cancer using Catalog No:114179(TTR antibody) at dilution of 1:100 (under 10x lens)
Immunohistochemical of paraffin-embedded human liver cancer using Catalog No:114179(TTR antibody) at dilution of 1:100 (under 40x lens)
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Background
Transthyretin (TTR) is a plasma transport protein for thyroxine and retinol, through the association with retinol-binding protein. It is a homotetrameric protein synthesized mainly in liver, choroid plexus, retinal pigment epithelium, and pancreas.Within the CNS, TTR is the only known protein synthesized solely by the choroid plexus. Mutant and wildtype TTR give rise to various forms of amyloid deposition (amyloidosis). Defects in TTR are the cause of amyloidosis transthyretin-related (AMYL-TTR),hyperthyroxinemia dystransthyretinemic euthyroidal (HTDE) and carpal tunnel syndrome type 1 (CTS1). In addition, positive immunostaining for TTR has been reported as a sensitive diagnostic marker of choroid plexus tumors. (22103483)
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References
- Iwasaki T, Kato M, Horie Y. A pediatric intramedullary spinal cord tumor with unusual solid-cystic and papillary features: a case report. Neuropathology : official journal of the Japanese Society of Neuropathology. 31(6):632-8. 2011.
- Kim JH, Lee SK, Yoo YC. Proteome analysis of human cerebrospinal fluid as a diagnostic biomarker in patients with meningioma. Medical science monitor : international medical journal of experimental and clinical research. 18(11):BR450-60. 2012.
- Puccini JM, Ruller CM, Robinson SM. Distinct neural stem cell tropism, early immune activation, and choroid plexus pathology following coxsackievirus infection in the neonatal central nervous system. Laboratory investigation; a journal of technical methods and pathology. 94(2):161-81. 2014.
- Lanctot AA, Peng CY, Pawlisz AS, Joksimovic M, Feng Y. Spatially dependent dynamic MAPK modulation by the Nde1-Lis1-Brap complex patterns mammalian CNS. Developmental cell. 25(3):241-55. 2013.
- Zemany L, Bhanot S, Peroni OD. Transthyretin Antisense Oligonucleotides Lower Circulating RBP4 Levels and Improve Insulin Sensitivity in Obese Mice. Diabetes. 64(5):1603-14. 2015.
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