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Product Name
OMA1 antibody
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Description
OMA1 Rabbit Polyclonal antibody. Positive IHC detected in human liver tissue. Positive WB detected in mouse liver tissue, K-562 cells. Observed molecular weight by Western-blot: 60 kDa
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Tested applications
ELISA, WB, IHC
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Species reactivity
Human,Mouse,Rat; other species not tested.
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Alternative names
2010001O09Rik antibody; DAB1 antibody; FLJ33782 antibody; MPRP 1 antibody; MPRP1 antibody; OMA1 antibody; YKR087C antibody; ZMPOMA1 antibody
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Isotype
Rabbit IgG
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Preparation
This antibody was obtained by immunization of OMA1 recombinant protein (Accession Number: NM_145243). Purification method: Antigen affinity purified.
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Clonality
Polyclonal
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Formulation
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
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Storage instructions
Store at -20℃. DO NOT ALIQUOT
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Applications
Recommended Dilution:
WB: 1:200-1:2000
IHC: 1:50-1:500
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Validations
mouse liver tissue were subjected to SDS PAGE followed by western blot with Catalog No:113346(OMA1 antibody) at dilution of 1:500
Immunohistochemistry of paraffin-embedded human liver tissue slide using Catalog No:113346(OMA1 Antibody) at dilution of 1:200 (under 10x lens).
Immunohistochemistry of paraffin-embedded human liver tissue slide using Catalog No:113346(OMA1 Antibody) at dilution of 1:200 (under 40x lens).
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Background
OMA1(Overlapping with the m-AAA protease 1 homolog) is also named as MPRP1(Metalloprotease-related protein 1) and belongs to the peptidase M48 family.It is a zinc metalloprotease that spans the inner mitochondrial membrane with a number of predicted membrane spanning domains and the 60 kDa form of OMA1 rapidly accumulated concomitantly with the cleavage of all OPA1 variants,and the 40 kDa form of OMA1 may be the inactive form, with the 60 kDa form being the active enzyme(PMID:20334834).This antibody is speicific to OMA1.
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References
- Baburamani AA, Hurling C, Stolp H. Mitochondrial Optic Atrophy (OPA) 1 Processing Is Altered in Response to Neonatal Hypoxic-Ischemic Brain Injury. International journal of molecular sciences. 16(9):22509-26. 2015.
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