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Product Name
Human OMA1 Recombinant protein (His tag)
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Description
Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. May also cleave UQCC3 under these conditions. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions. {UniProtKB:Q9D8H7, PubMed:20038677}.
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Protein name
Metalloendopeptidase OMA1, mitochondrial
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Protein short names
MPRP1
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Uniprot ID
Q96E52
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Gene Name
OMA1; MPRP1
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Source/Expression Host
E. coli
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Expression Plasmid/cDNA
A DNA sequence encoding the human OMA1 (NP_660286.1) 361-524 aa was fused with the polyhistidine tag
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Protein Species
Human
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Activity
Not tested.
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Validations
Recombinant human OMA1 SDS-PAGE
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